Formulation , characterization and In Vitro - In Vivo evaluation of Ketorolac - loaded Solid lipid nanoparticles for transdermal delivery

The present study was aimed at developing aqueous dispersion of Ketorolac-loaded solid lipid nanoparticles (SLN) by high speed stirring followed by ultrasonication technique and then incorporation into freshly prepared gel for transdermal delivery. A statistical central composite design was applied to study the effect of drug/lipid ratio and soya lecithin concentration on particle size and entrapment efficiency. The prepared formulations were characterized for in vitro release study. The anti-inflammatory effect of ketorolac-loaded solid lipid nanoparticles gel was assessed by carrageenan-induced paw edema model in rats and compared to ketorolac conventional gel. Both the ketorolac conventional gel and ketorolac-loaded SLN gel possessed a sustained drug release over period of 24 h but the sustained effect was more pronounced with the ketorolac-loaded solid lipid nanoparticles gel.